Following oral administration, both the active drug component quickly absorbed in the gastrointestinal tract nandrolon.
The bioavailability after oral administration of amoxicillin is 80%, does not affect food intake on the drug absorption. The time to maximum concentration nandrolonĀ is 1-2 hours half-life – 1 hour Plasma protein binding -. 20%. Amoxicillin is distributed in most tissues and body fluids, it crosses the placental barrier and is found in breast milk. Write mainly kidneys (glomerular filtration and tubular secretion) – 70-80%, and in the bile – 5-10%. Sulbactam pivoxil is hydrolyzed in the gastrointestinal tract to improve absorption of sulbactam. The time to maximum concentration nandrolon, as well as for amoxicillin is 1 -2 hours Linking proteins -. 40%. The half-life of 1 hour.
Sulbactam no effect on the pharmacokinetics of amoxicillin.

Indications
Bacterial infections caused by susceptible pathogens:

 

  • upper respiratory tract infections (bronchitis, pneumonia, empyema, lung abscess);
  • infection of upper respiratory tract (sinusitis, tonsillitis, otitis media);
  • biliary tract infection (cholangitis, cholecystitis), intestinal infections (dysentery, salmonellosis, salmonella carrier) for Helicobacter pylori eradication in the complex therapy;
  • infections of the genitourinary system and the pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, puerperal sepsis, pelvioperitonit, chancroid, gonorrhea);
  • infections of skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, cellulitis, wound infection);
  • postoperative infections.
    Prevention of infectious and inflammatory complications in surgery.Contraindications:
    Hypersensitivity to the drug and other beta-lactam antibiotics, infectious mononucleosis (including when a morbilliform rash), ulcerative colitis (including those associated with taking antibiotics), up to 2 years (recommended for children under 2 years nandrolon oral use in the form of a suspension).Be wary.
    Severe hepatic insufficiency, gastrointestinal disease (including a history of colitis associated with the use of penicillins), chronic renal failure . old age (due to the possible renal failure).

    Pregnancy and lactation.
    Use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. Nandrolon is excreted in breast milk, so breast-feeding should be discontinued, if necessary, the appointment during lactation.

    Dosing and Administration
    Inside, regardless of meals. Dosage regimen (dose given in terms of amoxicillin) set individually depending on the severity and localization of infection susceptibility. Adults and adolescents over 12 years appoint 250 mg 3 times a day. In severe infections, 500 mg 3 times daily or 1 g 2 times a day. A single dose is determined depending on the age:. For children aged 6-12 years – 250-500 mg, 2-6 years – 250 mg, the multiplicity of purposes – 3 times a day
    Eating does not affect the absorption of the drug. Duration of treatment -up to 14 days.
    In chronic renal insufficiency the dose is calculated according to the creatinine clearance. In this regard, for ease of selection of adequate doses recommended parenteral administration Trifamoksa IBL.

    Side effects From the digestive system: nausea, vomiting, diarrhea, abnormal liver function (increased activity of “liver” transaminases, in rare cases -holestaticheskaya jaundice, hepatitis), pseudomembranous colitis. Allergic reactions: urticaria, angioedema, rarely – exudative erythema multiforme , anaphylactic shock, angioneurotic edema, rarely – exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome). Other: candidiasis, superinfection development, reversible increase of prothrombin time.

     

    Overdose Symptoms: violation of gastrointestinal function (nausea, vomiting, diarrhea), and water and electrolyte balance. Treatment: symptomatic. Hemodialysis is effective.

     

    Interaction with other medicinal products
    Antacids, glucosamine, laxatives, drugs, aminoglycosides slow down and reduce absorption; Ascorbic acid enhances the absorption. Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) – antagonistic. It slows the excretion of methotrexate. It improves the effectiveness of indirect anticoagulants (you must follow the indicators of blood coagulation).
    It reduces the effectiveness of oral contraceptives, medicines, in the process of metabolism that produce para-aminobenzoic acid, ethinyl estradiol – the risk of bleeding “breakthrough.” Allopurinol increases the risk of skin rash.

    Cautions
    Prolonged use is necessary to monitor renal and hepatic function. The drug should be discontinued in the development of superinfection caused by nandrolon.