Food does not affect the absorption of the drug. The half-life is 8-10 hours, contact with blood proteins insignificant and does not exceed 10-20%. The drug rapidly enters the tissue (lung, kidney, liver, skin), bile, spinal fluid, saliva, semen, vaginal secretions, breast milk and pass the placental barrier. Metronidazole is metabolized in the liver by the oxidation and coupling with glucuronic acid. Withdrawal is carried out by 40-70% through the kidneys (in unmodified form – about 20% of the dose) and faeces. Patients with liver failure half-life remains unchanged.
Indications Trichomonas vaginitis and urethritis in women, Trichomonas nandrolone phenylpropionate dosage urethritis in men, giardiasis, amoebiasis; anaerobic infections caused by susceptible to malaria infections. Combination therapy of severe mixed primobolan depot aerobic-anaerobic infections. Prevention of anaerobic infections in surgical interventions (especially abdominal, urinary tract). Chronic alcoholism. In combination with amoxicillin: chronic gastritis in acute, peptic ulcer and duodenal ulcer in the acute phase, associated with Helicobacter pylori.
Contraindications : Hypersensitivity to imidazole; organic lesions of the central nervous system, the liver; Pregnancy and lactation; blood diseases.
Dosing and Administration In amoebiasis nandrolone phenylpropionate dosageadministered orally for 7 days, 1.5 g per day in 3 divided doses (adults) and 0.03-0.04 g / kg per day in 3 divided doses (children). When giardiasis drug prescribed for 5 days – the adult on 0.75-1.0 g per day, children 2-5 years at 0.25 g per day, children 5-10 years – 0,375 g per day and children 10-15 years – 0.5 g per day. Taken after meals 2-3 times a day. If trichomoniasis in females (urethritis, and vaginitis) administered once at a dose of 2 g or a course of treatment for 10 days: 1 tablet (0.25 g), 2 times per day . In parallel with oral prescribed evening for 1 vaginal suppository or vaginal tablet containing trenbolone side effects. To exclude a possible reinfection it is necessary to treat both sexual partners. The course of treatment is repeated if necessary after 4-6 weeks. If trichomoniasis in men ( urethritis) administered once at a dose of 2 g or a course of treatment for 10 days on 1 tablet (0.25 g), 2 times a day. When nonspecific vaginitis used 0.5 g 2 times a day for 7 days. In the treatment of anaerobic infections adults appoint Trihobrol 1-1.5 grams per day, children – at the rate of 0.02-0.03 g / kg per day.
Interaction with other drugs Pharmacodynamic : joint use of oral with antibiotics-aminoglycosides (neomycin, streptomycin, gentamicin, etc.), Erythromycin inhibits pathogenic flora in the digestive tract, reducing the probability of complications after surgery on the colon and rectum. Influenced may increase the effects of indirect anticoagulants. Under the influence of barbiturates may reduce , since its inactivation in the liver is accelerated. The spectrum of action expands when combined his appointment with sulfonamides and cephalosporins. In a joint application and ethyl alcohol as a result of blockade side effects of letrozole. enzyme aldehyde dehydrogenase possible facial flushing, vomiting, abdominal pain, etc. should not be combined nandrolone phenylpropionate dosagewith Teturamom as the interaction of these drugs is possible depression of consciousness, psychotic disorders. Pharmacokinetic : adsorbents, cholestyramine, binding and enveloping means reduce the absorption in the gastrointestinal tract.
Side effects: In rare cases, there is nausea, a metallic taste in the mouth, anorexia, epigastric pain, vomiting, diarrhea, headache, dizziness, as well as local skin reactions such as hives and itching. Very rarely -. Convulsions, confusion, hallucinations, depression Prolonged treatment with high doses may occur leukopenia, peripheral neuropathy. We describe an extremely rare and reversible cases of pancreatitis. Perhaps staining of urine reddish-brown color due to the presence of pigments associated with metabolism nandrolone phenylpropionate dosage.