With simultaneous use of tricyclic antidepressants and trazodone may cause cardiovascular side effects. Тandrolone phenylpropionate side effects inhibitors increase the risk of side effects. In a joint application increases the concentration of digoxin and phenytoin in blood plasma.
In vitro drug metabolism studies indicate the possibility of a pharmacological interaction with trazodone isoenzyme inhibitors of cytochrome , such as ketoconazole, ritonavir, indinavir and fluoxetine. Inhibitors isoenzyme may lead to a significant increase in the plasma concentration of trazodone, thereby increasing the likelihood of adverse events. Therefore, in case of receiving in combination with potent inhibitors isoenzyme trazodone dose should be reduced.
When trazodone in combination with carbamazepine plasma nandrolone phenylpropionate side effects trazodone concentration decreases. Therefore, patients simultaneously receiving trazodone and carbamazepine should be monitored carefully.
Pregnancy and lactation
The drug is not recommended for pregnant women.
The drug is not recommended for use during breastfeeding.
Suicide / suicidal thoughts or clinical worsening of symptoms:
When conditions are at increased risk of depressive manifestations of suicidal thoughts, self-harm or suicide. Risk can last before the pronounced remission. As improvement may not occur during the first few weeks of treatment or more, patients should be closely monitored prior to such improvements. According to the general clinical experience, the risk of suicide may increase in the early stages of recovery. It is known that patients with suicidal events in the history of, or patients who exhibit a significant degree of suicidal ideation prior to initiation of treatment, are at greater risk of suicidal thoughts or suicide attempts, and should be monitored closely during treatment. Results of a meta-analysis of placebo-controlled clinical studies of antidepressants, which are used in adults with psychiatric disorders showed an increased risk of suicidal behavior in patients younger than 24 years while taking antidepressants compared to placebo. Careful monitoring of patients, especially at high risk should accompany drug therapy, especially in its early stages and following dose changes. It nandrolone phenylpropionate side effects is necessary to warn patients (and caregivers) about the need to keep track of any clinical deterioration, suicidal behavior or suicidal thoughts and unusual changes in behavior, and immediately seek the advice of a specialist with the appearance of symptoms.
Since the drug has some adrenoblokiruyuschey activity, possibly bradycardia development and reduce blood pressure. Therefore, caution should be exercised when administering the drug to patients with a tendency to lengthen the interval QT, atrio-ventricular blockade of varying degrees of severity, patients with recent myocardial infarction.
When trazodone therapy in patients with bipolar disorder, depressive episodes can range from manic-depressive to manic psychosis. In these cases it is necessary to terminate treatment.
In epilepsy should take trazodone with caution, in particular avoiding sudden increases or decreases in dose.
With simultaneous use of trazodone with drugs having serotonergic activity (tricyclic antrideperssanty, selective serotonin reuptake inhibitors, norepinephrine reuptake inhibitors and serotonin and monoamine oxidase inhibitors), and neuroleptics, may cause serotonin syndrome.
With simultaneous use of trazodone with preparations containing St. John’s wort, side effects may be more frequent.
When using trazodone may develop agranulocytosis, so it is recommended to carry out studies of peripheral blood, especially in the presence of pain in the throat when swallowing, and fever appears.
Trazodone effective in sleep disorders in nandrolone phenylpropionate side effects patients with depression, increases the depth and duration of sleep, restores its physiological structure and quality.
The product has no effect on body weight.